What Is Brain Health? An 8-Pillar Framework for Protecting Your Brain

At NeuroVesa, our central goal is to help people improve their brain health. We believe the brain is your most important investment — everything you think, feel, and do originates there. Improve how your brain functions and everything downstream can improve too.

But that goal requires a clear starting point: what is brain health, exactly?

The honest answer is that no one fully agrees yet. With permission from the lead author, we adapted our working definition from a 2022 concept analysis in the International Journal of Geriatric Psychiatry — one of the most thorough efforts to synthesize definitions across the research literature:

Our Working Definition

Brain health is the dynamic state of brain function across cognitive, physical, and socio-emotional domains that results in a continuum of quality of life and wellness.

Adapted from Chen et al., 2022, International Journal of Geriatric Psychiatry

It is not a fixed destination. It is not the absence of disease, though disease erodes it. It exists on a spectrum, shifts across the lifespan, and is shaped by an accumulation of factors — many of which are modifiable.

Table of Contents


Why We're Not Waiting for Perfect Evidence

Cardiovascular medicine faced the same challenge. In the 1960s, heart disease was poorly understood and risk factors were debated. That didn't stop researchers and clinicians from acting on accumulating evidence — treating hypertension, recommending exercise, discouraging smoking — long before the full picture was clear. That pragmatic approach eventually produced a greater than 50% decline in cardiovascular mortality.

Brain health is now where cardiovascular health was then. The evidence is large, growing, and convergent enough to act on — even though formal proof of the kind that satisfies a randomized controlled trial remains elusive across most of the field. Acting on the best available evidence while being transparent about its limits is not a compromise. It is the rational response to a genuinely informative but incomplete body of science.

Analogy

Think of it like early cardiovascular medicine: doctors didn't wait until every mechanism was mapped before telling patients to stop smoking and start exercising. The direction of the evidence was clear, the cost of acting was near zero, and the cost of waiting was irreversible damage. Brain health is at that same inflection point now.


What This Framework Cannot Prove

We should be transparent about what the evidence cannot yet establish. Much of the research linking lifestyle factors to long-term brain outcomes comes from observational studies, which cannot prove causation. There are legitimate methodological concerns — confounding, reverse causation, healthy-user bias — and honest scientists disagree about the magnitude of benefit these interventions provide for late-life outcomes specifically. The long-term case is not as airtight as most brain health content implies.

But consider what this framework is actually asking you to do: sleep better, move your body, manage your cardiovascular risk factors, eat less processed food, treat your depression, challenge your brain, invest in your relationships, wear a helmet, and put an air filter in your bedroom. The downside of these actions if the dementia-specific evidence turns out to be overstated is — essentially nothing. Every pillar in this framework is independently beneficial for reasons that have nothing to do with dementia risk.

  • Exercise improves mood, focus, and stress resilience within weeks
  • Sleep quality directly affects next-day cognitive performance and emotional regulation
  • Treating depression produces measurable neurobiological improvements in the near term

These are not speculative bets. They are well-established interventions that improve how your brain functions today.

The science is refining the precision of future recommendations, not debating whether these behaviors are good for you. They are. The question is how much additional long-term brain protection they provide — and the honest answer is that we do not yet know exactly, but the direction of the evidence is clear and the cost of acting on it is zero.


A Note on Timing

One of the most counterintuitive findings in this field is that brain health is not primarily a concern for your seventies. Alzheimer's pathology begins accumulating fifteen to twenty years before symptoms appear. The risk factors with the strongest evidence consistently show their largest effects in midlife — roughly ages 40 to 65 — precisely because that window overlaps with the early accumulation phase when behavioral influences may matter most.

If you are in that window, this article is most directly addressed to you. If you are past it, it is still addressed to you — the brain retains meaningful plasticity well into later life. The window available to you now is always the most important one you still have access to.

What follows is NeuroVesa's interpretation of the current evidence — not the final word on brain health, and not a substitute for medical advice. We have done our best to represent the science accurately, to distinguish what is established from what is merely promising, and to be honest where the evidence has fallen short.


Pillar 1: Sleep

Sleep is when your brain does its maintenance work — consolidating memories, regulating emotional responses, restoring neurochemical balance, and clearing the metabolic waste that builds up while you're awake. When sleep is consistently poor, that maintenance doesn't happen. The downstream effects are immediate: reaction time slows, emotional regulation gets harder, motivation drops, and your capacity to exercise, manage stress, eat well, and stay socially connected — the other pillars of this framework — all become more difficult.

Sleep is not one factor among equals. It is the foundation the other pillars rest on.

What Most People Get Wrong

People who sleep poorly tend to focus on what time they go to bed. Sleep research consistently points to a different variable as more important — wake time consistency. Keeping the same wake time every day, including weekends, is the single most effective anchor for stabilizing your circadian rhythm. You go to bed when you're tired. You wake up at the same time regardless.

What to Do

Fix your wake time first. Set it and hold it seven days a week. Aim for 7–9 hours of total sleep, but build that duration backward from your anchor, not forward from an arbitrary bedtime. And if you snore heavily or feel unrested despite adequate hours, get evaluated for sleep apnea — it is one of the most underdiagnosed conditions in this space and is associated with accelerated Alzheimer's pathology.

Sleep is the foundation of the entire framework. Fixing your wake time consistency may be the single most accessible intervention for improving how your brain functions day to day.

Read the full guide: Sleep and Your Brain → coming soon

Pillar 2: Physical Activity

Exercise does more for your brain than any other single behavior in this framework. It drives the production of BDNF — a protein that helps form and maintain the neural connections underpinning learning, memory, and cognitive resilience. It improves blood flow to the brain, reduces inflammation, and lowers the cardiovascular and metabolic risk factors that directly accelerate brain aging.

What Most People Get Wrong

The mental model most people have is that exercise only "counts" if it's intense. For brain health, this is backwards. The largest cognitive return on exercise comes from the transition between doing nothing and doing something moderate. Going from sedentary to a regular brisk walking habit captures the majority of the brain health benefit. The person who walks 30 minutes a day for ten years is better off than the person who trains hard for three months and quits.

Analogy

Think of exercise like compound interest: small, consistent deposits matter far more than a few large ones followed by withdrawal. The 30-minute daily walk is your automatic monthly contribution. The intense-but-unsustainable workout is a one-time bonus that doesn't compound.

What to Do

Walk. That's the starting point if you're currently sedentary, and it's not a stepping stone to something harder — it's the intervention. Thirty minutes of brisk walking five days a week puts you in the range where the evidence is strongest. If you're already active, add strength training twice a week — there is emerging evidence it provides cognitive benefits through different pathways than aerobic exercise. But if you're choosing between a perfect program you won't sustain and a simple one you will, choose the simple one every time.

Physical activity has the strongest direct evidence for brain benefit of any behavior in this framework. The critical insight is that moderate, sustained activity outperforms intense, intermittent effort for long-term brain health.

Read the full guide: Exercise for Brain Health → coming soon

Pillar 3: Cardiovascular & Metabolic Health

Your brain consumes roughly 20% of your body's oxygen and energy despite being about 2% of your body weight. Every second of every day, it depends on your cardiovascular system to deliver that supply. When that system is compromised — by high blood pressure, high cholesterol, type 2 diabetes, or obesity — your brain is one of the first organs to feel it.

Most people think of these as heart problems. They are also brain problems. Midlife hypertension is one of the strongest and most consistent predictors of late-life dementia in the entire research literature.

What Most People Get Wrong

These conditions are silent. That's not a metaphor — hypertension, high cholesterol, insulin resistance, and early type 2 diabetes typically produce no symptoms at all during the years they are doing the most damage. Most people under 50 don't know their numbers because they feel fine. Feeling fine is not evidence that your vascular system is fine.

What to Do

If you are over 40 and have not had a recent blood panel, book one. This is arguably the single highest-leverage 30-minute investment in this entire framework, because you cannot manage what you have not measured. Get your blood pressure, fasting glucose, HbA1c, and lipid panel checked. If anything is out of range, work with your doctor to manage it — and understand that when you do, you are protecting your brain, not just your heart.

The cardiovascular system is the infrastructure your brain runs on. The most important action for many readers may be a simple blood panel they've been putting off — you cannot protect what you haven't measured.

Read the full guide: Your Heart, Your Brain → coming soon

Pillar 4: Nutrition

We want to be upfront about something: the direct evidence that any specific diet prevents cognitive decline is weaker than you might expect. Dietary patterns like the Mediterranean and MIND diets show promising associations with lower dementia risk in observational studies, but when the MIND diet was tested in a rigorous controlled trial (Barnes et al., 2023, NEJM), it did not outperform a standard healthy comparison diet. That is a meaningful result and we think it is important to acknowledge.

What the evidence does strongly support is that good nutrition is one of the most effective tools for protecting the systems your brain depends on. The cardiovascular and metabolic conditions from the previous pillar — hypertension, high cholesterol, type 2 diabetes, chronic inflammation — are all profoundly influenced by what you eat.

What Most People Get Wrong

The brain health nutrition conversation is dominated by what to add — blueberries, turmeric, omega-3 supplements, the latest superfood. The evidence points in the other direction. What you remove likely matters more than what you add. Ultra-processed food — the packaged, shelf-stable, engineered products that make up the majority of calories in the typical Western diet — is consistently associated with worse cardiovascular, metabolic, and inflammatory outcomes.

What to Do

Reduce ultra-processed food. That's the single dietary shift with the broadest evidence base for the cardiovascular and metabolic outcomes that matter most to your brain. You don't need a specialized brain diet to do this — cook more meals from whole ingredients, and the problem largely solves itself. Beyond that, prioritize protein for maintaining muscle mass and metabolic health, and include omega-3 fatty acids from whole food sources regularly.

No specific "brain diet" has proven superior in controlled trials. But the indirect path is clear: nutrition powerfully shapes the cardiovascular and metabolic systems your brain depends on. Focus on reducing ultra-processed food rather than chasing superfoods.

Read the full guide: Nutrition for Brain Health → coming soon

Pillar 5: Stress & Mental Health

Stress is a normal part of life, and your brain is built to handle it in short bursts. The problem is chronic stress — the kind that stays elevated for months or years without adequate recovery. When stress becomes chronic, it keeps your cortisol system running at levels designed for emergencies, and that sustained exposure damages the brain structures you depend on for memory, decision-making, and emotional regulation.

This pillar is different from the others because the most important action for many people is not a lifestyle change — it is getting treatment for a condition they may already have. The 2020 Lancet Commission on Dementia Prevention identified depression as one of twelve modifiable risk factors for dementia.

What Most People Get Wrong

People tend to treat depression and chronic anxiety as something to push through — a motivational problem, a rough patch, a personal failing. The neuroscience says otherwise. Untreated depression is actively damaging your brain on a structural level, and every year it goes untreated extends that damage. Getting help is not a self-care luxury. For someone with untreated depression, it is the single highest-leverage medical intervention in this entire framework — higher than exercise, higher than diet, higher than any supplement.

What to Do

If you have been experiencing persistent low mood, loss of motivation, sleep disruption, or difficulty concentrating for more than a few weeks, talk to a doctor. Not eventually. Now. Effective treatments exist — therapy, medication, or both — and they produce measurable neurobiological improvements.

If depression or anxiety is not the issue, but chronic stress is — stress research consistently shows that your brain's stress response is determined not by the stressor itself but by how your brain appraises two things: how much control you have, and how much uncertainty you face. When you notice stress escalating, ask two questions: What part of this can I actually control? and What specifically am I uncertain about? Then act only on the controllable part and name the uncertainty explicitly.

For someone with untreated depression, seeking treatment may be the single most impactful action in this entire framework. For chronic stress, the acute tool is deliberate reappraisal — separating what you can control from what you cannot.

Read the full guide: Stress, Depression, and Your Brain → coming soon

Pillar 6: Cognitive Engagement

Your brain adapts to what you ask of it. When you regularly challenge yourself with new learning, complex problem-solving, or unfamiliar skills, your brain builds and strengthens the neural connections that support memory, reasoning, and mental flexibility. The concept of cognitive reserve describes a well-documented phenomenon: people who spend their lives engaged in cognitively demanding activities can tolerate more physical brain damage before showing symptoms of decline.

What Most People Get Wrong

This is the pillar where the gap between what people believe and what the evidence supports is widest. Most people think they're cognitively engaged because they do crossword puzzles, play Sudoku, or use a brain training app. The evidence says this barely counts. Once an activity becomes routine — once your brain has learned the pattern and can execute it without real effort — it stops building reserve. The ingredient that matters is not mental activity. It is struggle.

What to Do

If you're currently doing nothing cognitively demanding outside of your daily routine, start anywhere. Pick up a book on a subject you know nothing about. Try a free online course. Download a language app and commit to fifteen minutes a day. Push toward the things that make you feel genuinely incompetent — a musical instrument, a new language, a skill where you have no foundation. That frustration of being bad at something new is the signal that your brain is doing the kind of work that builds reserve.

Analogy

Cognitive engagement works like physical exercise: your muscles don't grow from movements that feel easy. They grow from resistance — from being pushed beyond what they can currently handle. Your brain builds new connections the same way: not from repeating what's comfortable, but from struggling with what's unfamiliar.

The specific activity matters far less than whether it forces your brain into real problem-solving rather than pattern repetition. If it's comfortable, it's not working. But if you're starting from nothing, even mild discomfort counts.

Read the full guide: Cognitive Engagement — What Actually Works → coming soon

Pillar 7: Social Connection

Humans are fundamentally social animals, and your brain reflects that. The neural systems that manage social interaction — reading intentions, navigating complex conversations, managing emotional responses, maintaining relationships — are among the most demanding things your brain does. When those systems are regularly engaged, they stay sharp. When they aren't, they atrophy.

What makes social connection particularly powerful is that it doesn't operate independently from the other pillars. Socially connected people are more likely to exercise, sleep better, manage stress more effectively, and stay cognitively engaged. Social connection acts as a behavioral multiplier across the entire framework.

What Most People Get Wrong

Most people evaluate their social health by how many people they know or how often they're around others. The evidence suggests this is the wrong metric. What predicts cognitive outcomes is not network size or social frequency but the emotional depth and reciprocity of your relationships. A person who has three close relationships where they feel genuinely known is in a fundamentally different position than someone who has a large social circle of surface-level contacts.

The second misconception is about when isolation becomes dangerous. The pattern usually starts much earlier than old age. It begins with small, reasonable withdrawals during busy career years, stressful life transitions, or periods of low mood. Each individual withdrawal feels temporary and justified. The cumulative effect, compounded over a decade or two, is a social network that has quietly hollowed out by the time you need it most.

What to Do

Audit the depth of your social connections, not the breadth. Ask yourself honestly: how many people in your life would you call at 2 AM in a genuine crisis? If that number is zero or one, this pillar is talking to you, regardless of how active your social calendar looks. The goal is not to accumulate more contacts — it is to invest in the relationships where genuine emotional exchange actually happens.

Social connection is a behavioral multiplier — it strengthens every other pillar. The metric that matters is not how many people you know but how many relationships involve genuine emotional depth and reciprocity.

Read the full guide: Social Connection and Brain Health → coming soon

Pillar 8: Environmental Factors

The other seven pillars focus on what you do. This one focuses on what you're exposed to — and it's the pillar most people have never thought about in the context of brain health.

Your brain is sensitive to its environment in ways that are invisible and easy to overlook. The 2020 Lancet Commission on Dementia Prevention included three environmental factors among its modifiable risk factors: air pollution, traumatic brain injury, and hearing loss. These are not exotic concerns. They are population-level exposures with strong evidence bases that most brain health advice simply ignores.

What Most People Get Wrong

People tend to think of brain health as something shaped entirely by their own choices. This pillar is the corrective. Some of the most significant modifiable risk factors for dementia are things that happen to you, not things you do. And unlike the behavioral pillars, where the brain can often recover from past neglect, many environmental exposures are cumulative and some are irreversible.

What to Do

This pillar is actually the most immediately actionable in the framework, because the interventions are simple, concrete, and available today:

  • Protect your head — wear a helmet for any activity with impact risk, and take head injuries seriously even when they seem minor
  • Protect your hearing — use hearing protection in loud environments, keep headphone volumes moderate, and get your hearing tested regularly after age 50
  • Reduce air pollution exposure — a HEPA filter in the room where you sleep, checking air quality indices before outdoor exercise, keeping car windows closed in heavy traffic

None of these require a lifestyle overhaul. They require awareness that the exposure exists and a few inexpensive, low-effort habits to reduce it.

Environmental factors are the most overlooked pillar — and paradoxically the most immediately actionable. Prevention matters more here than anywhere else in this framework, because many environmental exposures are cumulative and some are irreversible.

Read the full guide: Environmental Factors and Brain Health → coming soon

Connecting the Pillars

If you've read through all eight pillars, you've already noticed that they don't operate independently. Sleep enables exercise. Exercise reduces stress. Stress drives social withdrawal. Social connection reinforces every other habit. Cardiovascular health is the physiological infrastructure beneath all of it. This framework is not a checklist. It is a system — and systems respond best when you find the right entry point rather than trying to optimize everything at once.

Where to Start

If all eight pillars feel overwhelming, ignore most of them. Find the one or two that are most relevant to where you are right now, and start there. The interconnections mean that meaningful progress on one pillar tends to create momentum across others.

  • Start with sleep if you are currently getting fewer than seven hours, or your sleep quality is poor. Fix your wake time, hold it consistently, and you unlock the foundation the other pillars rest on.
  • Start with movement if you are largely sedentary. A daily brisk walk has the strongest direct evidence for brain benefit of any single behavior in this framework.
  • Start with treatment if you are dealing with untreated depression, anxiety, or a known cardiovascular or metabolic condition. These are active barriers that undermine everything else.

If you're tempted to tackle all three at once, resist. Pick the one that resonates most and give it four weeks before adding another. Consistency on one pillar will do more for your brain than a brief sprint across several.

The Evidence for a Multi-Domain Approach

The strongest evidence for this interconnected approach comes from the FINGER trial — a landmark 2015 study that randomized 1,260 older adults at elevated dementia risk to a two-year intervention combining structured exercise, nutritional guidance, cognitive training, social activity, and cardiovascular risk monitoring. The intervention group showed 25% greater improvement in overall cognition versus controls, with the strongest gains in executive function and processing speed.

What the FINGER trial establishes is a proof of concept: the multi-domain approach produces measurable cognitive benefits in a controlled setting. It does not prove that reading an article and making lifestyle changes on your own will produce the same results. The honest framing is that the evidence supports the direction of this framework, while the magnitude of benefit you can expect from self-directed changes is less certain. That uncertainty is not a reason to do nothing. It is a reason to act on the best available evidence while staying honest about its limits.

The pillars are interconnected: progress on one creates momentum across others. Start with the single pillar most relevant to your situation, give it four weeks, and build from there.


Where to Go from Here

This article gives you the framework. The guides below give you the specifics — the detailed evidence, the things to avoid, the practical protocols for each pillar. Choose the one most relevant to where you are right now.

Sleep and Your Brain

Coming soon

Exercise for Brain Health

Coming soon

Your Heart, Your Brain

Coming soon

Nutrition for Brain Health

Coming soon

Stress, Depression, and Your Brain

Coming soon

Cognitive Engagement: What Actually Works

Coming soon

Social Connection and Brain Health

Coming soon

Environmental Factors and Brain Health

Coming soon

If you take one thing from this article, let it be this: the window available to you right now is always the most important one you still have access to. The people who benefit most are not the ones who do everything perfectly, but the ones who start, stay consistent, and build from there.


Frequently Asked Questions

Is it too late to improve my brain health if I'm over 65?

No. While the evidence for the largest effects centers on midlife (40–65), the brain retains meaningful plasticity throughout life. The FINGER trial showed cognitive benefits in adults aged 60–77. Exercise produces BDNF increases at any age. Treating depression and managing cardiovascular risk factors yield neurobiological improvements regardless of when you start. The window you have now is always the most important one.

Which pillar should I start with?

Start with whichever pillar addresses your most pressing issue. If you sleep poorly, start with sleep — it's the foundation. If you're sedentary, start with a daily walk. If you have untreated depression or an unmanaged cardiovascular condition, start with treatment. Pick one pillar, give it four weeks of consistency, then consider adding another.

Do brain training apps actually work?

The evidence for broad cognitive transfer from commercial brain training programs is weak. A large trial (Owen et al., 2010) found no evidence that brain training improved general cognitive function — you get better at the game, but the benefits don't transfer. For building genuine cognitive reserve, the evidence points toward learning truly new, challenging skills — a new language, a musical instrument, or any domain where you're starting from scratch.

Does the MIND diet prevent dementia?

In observational studies, the MIND diet shows promising associations with lower dementia risk. However, when tested in a rigorous controlled trial (Barnes et al., 2023), it did not outperform a standard healthy comparison diet. What the evidence does strongly support is that good nutrition protects the cardiovascular and metabolic systems your brain depends on. The takeaway: eat well for your vascular health, but don't expect a specific diet to be a dementia "cure."

How much exercise do I need for brain health benefits?

Thirty minutes of brisk walking five days a week puts you in the range where the evidence is strongest. The critical insight is that the largest benefit comes from the transition between doing nothing and doing something moderate. If you're currently sedentary, a daily walk captures the majority of the brain health benefit. More intense exercise adds relatively little beyond that baseline.

Can supplements protect my brain?

This article focuses on the lifestyle and behavioral factors with the strongest evidence base. Some supplements show promising early data for specific aspects of brain function, and NeuroVesa explores the evidence for individual ingredients in our dedicated articles. But no supplement substitutes for the fundamentals covered in this framework — sleep, exercise, cardiovascular health, and the other pillars should be your foundation.

Why does this article acknowledge limitations in the evidence?

Because honesty builds trust, and most brain health content overpromises. Much of the research linking lifestyle to long-term brain outcomes is observational and cannot prove causation. We believe you deserve to know that — and we believe the framework is still worth acting on, because every pillar is independently beneficial for your health today, regardless of the long-term dementia-specific evidence.


References

  1. Chen Y, Demnitz N, Yamamoto S, Yaffe K, Lawlor B, Leroi I. "Defining brain health: A concept analysis." International Journal of Geriatric Psychiatry, vol. 37, no. 1, 2022. DOI
  2. Ford ES, Ajani UA, Croft JB, et al. "Explaining the decrease in U.S. deaths from coronary disease, 1980–2000." New England Journal of Medicine, vol. 356, no. 23, pp. 2388–2398, 2007. DOI
  3. Bateman RJ, Xiong C, Benzinger TLS, et al. "Clinical and biomarker changes in dominantly inherited Alzheimer's disease." New England Journal of Medicine, vol. 367, no. 9, pp. 795–804, 2012. DOI
  4. Livingston G, Huntley J, Sommerlad A, et al. "Dementia prevention, intervention, and care: 2020 report of the Lancet Commission." The Lancet, vol. 396, no. 10248, pp. 413–446, 2020. DOI
  5. Jessen NA, Munk ASF, Lundgaard I, Bhatt DK. "The glymphatic system: A beginner's guide." Neurochemical Research, vol. 40, no. 12, pp. 2583–2599, 2015. DOI
  6. Sabia S, Fayosse A, Dumurgier J, et al. "Association of sleep duration in middle and old age with incidence of dementia." Nature Communications, vol. 12, no. 1, p. 2289, 2021. DOI
  7. Sharma RA, Varga AW, Bubu OM, et al. "Obstructive sleep apnea severity affects amyloid burden in cognitively normal elderly." American Journal of Respiratory and Critical Care Medicine, vol. 197, no. 7, pp. 933–943, 2018. DOI
  8. Walsh JJ, Tschakovsky ME. "Exercise and circulating BDNF: mechanisms of release and implications for the design of exercise interventions." Applied Physiology, Nutrition, and Metabolism, vol. 43, no. 11, pp. 1095–1104, 2018. DOI
  9. Erickson KI, Voss MW, Prakash RS, et al. "Exercise training increases size of hippocampus and improves memory." Proceedings of the National Academy of Sciences, vol. 108, no. 7, pp. 3017–3022, 2011. DOI
  10. Barnes LL, Dhana K, Liu X, et al. "Trial of the MIND diet for prevention of cognitive decline in older persons." New England Journal of Medicine, vol. 389, no. 7, pp. 602–611, 2023. DOI
  11. Gonçalves NG, Vidal Ferreira N, Khandpur N, et al. "Ultra-processed food consumption and cognitive decline in the ELSA-Brasil cohort." JAMA Neurology, vol. 80, no. 2, pp. 142–150, 2023. DOI
  12. Lupien SJ, McEwen BS, Gunnar MR, Heim C. "Effects of stress throughout the lifespan on the brain, behaviour and cognition." Nature Reviews Neuroscience, vol. 10, no. 6, pp. 434–445, 2009. DOI
  13. Schmaal L, Veltman DJ, van Erp TGM, et al. "Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group." Molecular Psychiatry, vol. 21, no. 6, pp. 806–812, 2016. DOI
  14. Stern Y. "Cognitive reserve in ageing and Alzheimer's disease." The Lancet Neurology, vol. 11, no. 11, pp. 1006–1012, 2012. DOI
  15. Owen AM, Hampshire A, Grahn JA, et al. "Putting brain training to the test." Nature, vol. 465, no. 7299, pp. 775–778, 2010. DOI
  16. Kuiper JS, Zuidersma M, Oude Voshaar RC, et al. "Social relationships and risk of dementia: a systematic review and meta-analysis of longitudinal cohort studies." Ageing Research Reviews, vol. 22, pp. 39–57, 2015. DOI
  17. Lin FR, Pike JR, Albert MS, et al. "Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial." The Lancet, vol. 402, no. 10404, pp. 786–797, 2023. DOI
  18. Ngandu T, Lehtisalo J, Solomon A, et al. "A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial." The Lancet, vol. 385, no. 9984, pp. 2255–2263, 2015. DOI
  19. Kivipelto M, Mangialasche F, Snyder HM, et al. "World-Wide FINGERS Network: a global approach to risk reduction and prevention of dementia." Alzheimer's & Dementia, vol. 16, no. 7, pp. 1078–1094, 2020. DOI

This article is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before making changes to your health regimen. NeuroVesa is committed to updating this framework as new evidence emerges. If you believe we have misrepresented the science on any point, we welcome correction — contact us at support@neurovesa.com.